Nucleophilic-Aromatic-Substitutions

Last updated July 1, 2022

nucleophilic-substitutions

• A nucleophile (Nu-) attack an electron poor aromatic molecule, resulting in the substitution of a leaving group
• Works well with electron withdrawing groups (EWG), such as NO2, since it activates the ring
• The EWGs work well in the ortho or para positions since the Nu- puts a negative charge on the ring and the EWG can help stabilize it

https://www.masterorganicchemistry.com/2018/08/20/nucleophilic-aromatic-substitution-nas/

https://en.wikipedia.org/wiki/Nucleophilic_aromatic_substitution

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Weickgenannt_Jun_12.pdf

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Weickgenannt_Jun_12.pdf

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

References:
 [0]  Weickgenannt_Jun_12.pdf

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Weickgenannt_Jun_12.pdf

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R10 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Weickgenannt_Jun_12.pdf

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Weickgenannt_Jun_12.pdf

Condition to enforce:

R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
 [4]  Explain why the trifluoromethyl (CF_3) group is meta directing in electrophilic aromatic substitution. What would you expect CF_3 to be activating or deactivating? Why? Can some one PLEASE help me!!!!! Thanks? | Socratic

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
 [4]  Explain why the trifluoromethyl (CF_3) group is meta directing in electrophilic aromatic substitution. What would you expect CF_3 to be activating or deactivating? Why? Can some one PLEASE help me!!!!! Thanks? | Socratic

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
 [4]  Explain why the trifluoromethyl (CF_3) group is meta directing in electrophilic aromatic substitution. What would you expect CF_3 to be activating or deactivating? Why? Can some one PLEASE help me!!!!! Thanks? | Socratic

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
 [4]  Explain why the trifluoromethyl (CF_3) group is meta directing in electrophilic aromatic substitution. What would you expect CF_3 to be activating or deactivating? Why? Can some one PLEASE help me!!!!! Thanks? | Socratic

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Weickgenannt_Jun_12.pdf

Condition to enforce:

R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Chichibabin reaction - Wikipedia

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
 [4]  Explain why the trifluoromethyl (CF_3) group is meta directing in electrophilic aromatic substitution. What would you expect CF_3 to be activating or deactivating? Why? Can some one PLEASE help me!!!!! Thanks? | Socratic

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
 [4]  Explain why the trifluoromethyl (CF_3) group is meta directing in electrophilic aromatic substitution. What would you expect CF_3 to be activating or deactivating? Why? Can some one PLEASE help me!!!!! Thanks? | Socratic

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Weickgenannt_Jun_12.pdf

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
 [4]  Explain why the trifluoromethyl (CF_3) group is meta directing in electrophilic aromatic substitution. What would you expect CF_3 to be activating or deactivating? Why? Can some one PLEASE help me!!!!! Thanks? | Socratic

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R10 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Weickgenannt_Jun_12.pdf

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
 [4]  Explain why the trifluoromethyl (CF_3) group is meta directing in electrophilic aromatic substitution. What would you expect CF_3 to be activating or deactivating? Why? Can some one PLEASE help me!!!!! Thanks? | Socratic

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Weickgenannt_Jun_12.pdf

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Weickgenannt_Jun_12.pdf

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R10 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Weickgenannt_Jun_12.pdf

Condition to enforce:

R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
 [4]  Explain why the trifluoromethyl (CF_3) group is meta directing in electrophilic aromatic substitution. What would you expect CF_3 to be activating or deactivating? Why? Can some one PLEASE help me!!!!! Thanks? | Socratic

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Weickgenannt_Jun_12.pdf

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Weickgenannt_Jun_12.pdf

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Weickgenannt_Jun_12.pdf

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
 [4]  Explain why the trifluoromethyl (CF_3) group is meta directing in electrophilic aromatic substitution. What would you expect CF_3 to be activating or deactivating? Why? Can some one PLEASE help me!!!!! Thanks? | Socratic

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
 [4]  Explain why the trifluoromethyl (CF_3) group is meta directing in electrophilic aromatic substitution. What would you expect CF_3 to be activating or deactivating? Why? Can some one PLEASE help me!!!!! Thanks? | Socratic

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Weickgenannt_Jun_12.pdf

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
 [4]  Explain why the trifluoromethyl (CF_3) group is meta directing in electrophilic aromatic substitution. What would you expect CF_3 to be activating or deactivating? Why? Can some one PLEASE help me!!!!! Thanks? | Socratic

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R10 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Weickgenannt_Jun_12.pdf

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
 [4]  Explain why the trifluoromethyl (CF_3) group is meta directing in electrophilic aromatic substitution. What would you expect CF_3 to be activating or deactivating? Why? Can some one PLEASE help me!!!!! Thanks? | Socratic

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
 [4]  Explain why the trifluoromethyl (CF_3) group is meta directing in electrophilic aromatic substitution. What would you expect CF_3 to be activating or deactivating? Why? Can some one PLEASE help me!!!!! Thanks? | Socratic

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

References:
 [0]  Weickgenannt_Jun_12.pdf

Condition to enforce:

R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
 [4]  Explain why the trifluoromethyl (CF_3) group is meta directing in electrophilic aromatic substitution. What would you expect CF_3 to be activating or deactivating? Why? Can some one PLEASE help me!!!!! Thanks? | Socratic

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [1]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [2]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [3]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne
 [4]  Explain why the trifluoromethyl (CF_3) group is meta directing in electrophilic aromatic substitution. What would you expect CF_3 to be activating or deactivating? Why? Can some one PLEASE help me!!!!! Thanks? | Socratic

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  Acetoacetic-Ester Synthesis
 [1]  Substituted carbonyl compound synthesis by alkylation or condensation
 [2]  Malonic Ester Synthesis
 [3]  Carbonyl alpha-substitution reactions - Wikipedia

Condition to enforce:

R1 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R3 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R5 = L-A, A-Aliphatic-Carbon, H, Nitrite, Nitrile, Chlorine, Bromine, Iodine, Fluorine, Halocarbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon

At least one logic:

Molecule conditions:
list_of_labels = R1, R3, R5
list_of_matching = (NO2L, Nitrite), (C#N[L], Nitrile), (ClL, Chlorine), (BrL, Bromine), (IL, Iodine), (FL, Fluorine), (CX3L, Halocarbon)

References:
 [0]  organic chemistry - Why does nucleophilic aromatic substitution occur at C-2 and C-4 of pyridine? - Chemistry Stack Exchange
 [1]  Nucleophilic Aromatic Substitution: Introduction and Mechanism
 [2]  16.7: Nucleophilic Aromatic Substitution - Chemistry LibreTexts
 [3]  Nucleophilic Aromatic Substitution - Chemistry Steps
 [4]  Organic chemistry 29: Aromaticity - nucleophilic aromatic substitution, benzyne

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

References:
 [0]  Vicarious nucleophilic substitution - Wikipedia
 [1]  Just a moment…

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon