Index

Carbonyl-Nucleophilic-Addition-Nu-Thiolate

References: 0,1,2

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Avoid formation of:

fragment = 3-membered-ring, 4-membered-ring, A-Cyclobutene-Aromatic, bridged_para_tether_2, bridged_para_tether_3, bridged_para_tether_4, bridged_para_tether_5, bridged_meta_tether_1, bridged_meta_tether_2, bridged_meta_tether_3, bridged_meta_tether_4, bridged_meta_tether_5

Reactants

Products

Amide-Carbonyl-Addition

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon
R2 = H, A-Aliphatic-Carbon
R3 = H, A-Aliphatic-Carbon
R4 = H, A-Aliphatic-Carbon

Reactants

Products

Carbonyl-Nucleophilic-Addition-Enols

References: 0,1,2,3,4,5,6

Special Conditions : REACT WITH ITSELF

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group, Bromine, Chlorine
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group, A-Alkoxide
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group, A-Alkoxide
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group, A-Alkoxide

Condition to avoid:

R3 = 3-membered-ring-L
R4 = 3-membered-ring-L

Avoid formation of:

fragment = 3-membered-ring, 4-membered-ring, A-Cyclobutene-Aromatic, bridged_para_tether_2, bridged_para_tether_3, bridged_para_tether_4, bridged_para_tether_5, bridged_meta_tether_1, bridged_meta_tether_2, bridged_meta_tether_3, bridged_meta_tether_4, bridged_meta_tether_5

Reactants

Products

DHU-Substitution-Amine

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Henry-Reaction

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Avoid formation of:

fragment = 3-membered-ring, 4-membered-ring, A-Cyclobutene-Aromatic, bridged_para_tether_2, bridged_para_tether_3, bridged_para_tether_4, bridged_para_tether_5, bridged_meta_tether_1, bridged_meta_tether_2, bridged_meta_tether_3, bridged_meta_tether_4, bridged_meta_tether_5

Reactants

Products

Carbonyl-Nucleophilic-Addition-Nu-Phosphine

References: 0,1,2

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Avoid formation of:

fragment = 3-membered-ring, 4-membered-ring, A-Cyclobutene-Aromatic, bridged_para_tether_2, bridged_para_tether_3, bridged_para_tether_4, bridged_para_tether_5, bridged_meta_tether_1, bridged_meta_tether_2, bridged_meta_tether_3, bridged_meta_tether_4, bridged_meta_tether_5

Reactants

Products

Carbonyl-Nucleophilic-Addition-Nu-Nitrile

References: 0,1,2

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Avoid formation of:

fragment = 3-membered-ring, 4-membered-ring, A-Cyclobutene-Aromatic, bridged_para_tether_2, bridged_para_tether_3, bridged_para_tether_4, bridged_para_tether_5, bridged_meta_tether_1, bridged_meta_tether_2, bridged_meta_tether_3, bridged_meta_tether_4, bridged_meta_tether_5

Reactants

Products

DHU-Substitution-Alcohol

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Carbonyl-Nucleophilic-Addition-Nu-Alkoxide

References: 0,1,2

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Avoid formation of:

fragment = 3-membered-ring, 4-membered-ring, A-Cyclobutene-Aromatic, bridged_para_tether_2, bridged_para_tether_3, bridged_para_tether_4, bridged_para_tether_5, bridged_meta_tether_1, bridged_meta_tether_2, bridged_meta_tether_3, bridged_meta_tether_4, bridged_meta_tether_5

Reactants

Products

Diimide-Carboxylic-Addition

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Cyanomethanide-Carbonyl-Addition

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Avoid formation of:

fragment = 4-membered-ring, A-Cyclobutene-Aromatic

Reactants

Products

Carbonyl-Nucleophilic-Addition-Nu-Amino

References: 0,1,2

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Avoid formation of:

fragment = 3-membered-ring, 4-membered-ring, A-Cyclobutene-Aromatic, bridged_para_tether_2, bridged_para_tether_3, bridged_para_tether_4, bridged_para_tether_5, bridged_meta_tether_1, bridged_meta_tether_2, bridged_meta_tether_3, bridged_meta_tether_4, bridged_meta_tether_5

Reactants

Products