Index

Conrad-Limpach-Synthesis-Thermodynamic

References: 0,1

Condition to enforce:

R5 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Pyrazole-Synthesis-Nitrile

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A

Reactants

pH: neutral | no catalyst no_water solvent any temperature

Products

Borsche-Drechsel-Cyclization

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = L-A

Reactants

pH: neutral | no catalyst any solvent any temperature

Products

Tetrazole-Formation

References: 0,1


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent high temperature

Products

VanLeusen-oxazole-synthesis

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon

Reactants

pH: neutral | no catalyst no_water solvent high temperature

Products

Hantzsch-Thiazole-Synthesis-X-Chlorine

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A

Reactants

pH: neutral | no catalyst no_water solvent any temperature

Products

Isoindolinone-Synthesis-1-X-Fluorine

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = H, A-Aliphatic-Carbon
R6 = L-A
R7 = L-A
R8 = L-A
R9 = L-A
R10 = L-A

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Pyrimidine-Synthesis

References: 0

Condition to enforce:

R1 = L-A
R2 = H, A-Aliphatic-Carbon
R3 = H, A-Aliphatic-Carbon
R4 = H, A-Aliphatic-Carbon

Reactants

pH: neutral | no catalyst water solvent any temperature

Products

Pyrazole-Synthesis-OO

References: 0,1

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Bohlmann-Rahtz-Pyridine-Synthesis-EWG-Nitrile

References: 0

Condition to enforce:

R1 = L-A, Vinyl-Group
R2 = L-A, Vinyl-Group

Avoid formation of:

fragment = 4-membered-ring

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Quinazoline-Synthesis

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = L-A

Reactants

no pH | no catalyst no_water solvent any temperature

Products

Benzimidazolone-Synthesis-1-X-Iodine

References: 0

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: neutral | no catalyst no_water solvent high temperature

Products

Cyclopropanation-Part-2

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon
R2 = H, A-Aliphatic-Carbon
R3 = H, A-Aliphatic-Carbon
R4 = H, A-Aliphatic-Carbon
R5 = H, A-Aliphatic-Carbon
R6 = H, A-Aliphatic-Carbon

Reactants

pH: neutral | no catalyst no_water solvent any temperature

Products

Benzoimidazole-Synthesis-2

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = H, A-Aliphatic-Carbon

Reactants

no pH | no catalyst water solvent high temperature

Products

Bohlmann-Rahtz-Pyridine-Synthesis-EWG-Nitrite

References: 0

Condition to enforce:

R1 = L-A, Vinyl-Group
R2 = L-A, Vinyl-Group

Avoid formation of:

fragment = 4-membered-ring

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Pfitzinger-Reaction

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst water solvent high temperature

Products

Madelung-Indole-Synthesis

References: 0,1

Condition to enforce:

R5 = H, A-Aliphatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent any temperature

Products

Kostaneki-Acylation-2

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = L-A, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent any temperature

Products

Indole-Synthesis-Nenitzescu

References: 0,1

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = L-A, A-Aromatic-Carbon
R7 = L-A, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Bradsher-Cyclization-2

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = L-A, A-Aromatic-Carbon
R7 = L-A, A-Aromatic-Carbon
R8 = L-A, A-Aromatic-Carbon
R9 = L-A, A-Aromatic-Carbon
R10 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

pH: acid | no catalyst no_water solvent room temperature

Products

Carbazole-Synthesis

References: 0

Condition to enforce:

R1 = L-A
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon

Reactants

pH: neutral | no catalyst no_water solvent high temperature

Products

Auwers-Synthesis

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = L-A, A-Aliphatic-Carbon
R3 = L-A, A-Aliphatic-Carbon
R4 = L-A, A-Aliphatic-Carbon
R5 = L-A, A-Aliphatic-Carbon

Reactants

pH: basic | no catalyst water solvent any temperature

Products

Guareschi-Thorpe-Condensation

References: 0,1

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent room temperature

Products

Fischer-oxazole-synthesis

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Huigsen-Cycloaddition

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: neutral | no catalyst no_water solvent high temperature

Products

Oxindole-Synthesis-X-Bromine

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Knorr-Quinoline-Synthesis

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R5 = H, A-Aliphatic-Carbon
R6 = H, A-Aliphatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Pomeranz-Fritsch-Reaction

References: 0

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Oxazole-Synthesis-EWG-Carbonyl-EWG3-Nitrile

References: 0

Condition to enforce:

R1 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Oxazole-Synthesis-EWG-Phosphonate-EWG3-Nitrile

References: 0

Condition to enforce:

R1 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Sandmeyer-Isatin-2

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst water solvent room temperature

Products

Iodine-Mediated-Cyclization-Indoline-Dihydroquinolone

References: 0

Condition to enforce:

R6 = A-Aliphatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent any temperature

Products

Bohlmann-Rahtz-Pyridine-Synthesis-EWG-Carbonyl

References: 0

Condition to enforce:

R1 = L-A, Vinyl-Group
R2 = L-A, Vinyl-Group
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Avoid formation of:

fragment = 4-membered-ring

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Oxazole-Synthesis-EWG-Nitrile-EWG3-Nitrile

References: 0

Condition to enforce:

R1 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Pyrazole-Synthesis-SO

References: 0,1

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst water solvent high temperature

Products

Pechmann-Condensation

References: 0,1

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Oxindole-Synthesis-X-Chlorine

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Allan-Robinson-Reaction

References: 0

Condition to enforce:

R5 = L-A
R6 = L-A
R7 = L-A

Reactants

pH: basic | no catalyst no_water solvent high temperature

Products

Pyrazole-Synthesis-Beta-Ketoester

References: 0,1

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: neutral | no catalyst no_water solvent any temperature

Products

Conrad-Limpach-Synthesis-Kinetic

References: 0,1

Condition to enforce:

R5 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent room temperature

Products

Hydrazine-Cyclization-Chlorine

References: 0

Reactants

pH: neutral | no catalyst water solvent any temperature

Products

Hantzsch-Pyrrole-Synthesis

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = H

Reactants

pH: neutral | no catalyst no_water solvent high temperature

Products

Skraup-Quinoline-Synthesis

References: 0,1


Special Conditions : SIDE REACTION

Condition to enforce:

R5 = H, A-Aliphatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon
R8 = H, A-Aliphatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Hantzsch-Thiazole-Synthesis-X-Bromine

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A

Reactants

pH: neutral | no catalyst no_water solvent any temperature

Products

Pyrazole-Synthesis-SS

References: 0,1

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst water solvent high temperature

Products

Oxindole-Synthesis-X-Iodine

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Bohlmann-Rahtz-Pyridine-Synthesis-EWG-Phosphonate

References: 0

Condition to enforce:

R1 = L-A, Vinyl-Group
R2 = L-A, Vinyl-Group
R3 = L-A
R4 = L-A

Avoid formation of:

fragment = 4-membered-ring

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Isoindolinone-Synthesis-1-X-Iodine

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = H, A-Aliphatic-Carbon
R6 = L-A
R7 = L-A
R8 = L-A
R9 = L-A
R10 = L-A

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Paal-Knorr-Pyrrole-Synthesis

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: neutral | no catalyst no_water solvent any temperature

Products

Barton-Zard-Reaction-NO2

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

pH: basic | no catalyst no_water solvent room temperature

Products

Indole-Synthesis-Hemetsberger-Knittel

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon

Reactants

pH: neutral | no catalyst no_water solvent high temperature

Products

Hantzsch-Thiazole-Synthesis-X-Sulfonate

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A

Reactants

pH: neutral | no catalyst no_water solvent any temperature

Products

Oxazole-Synthesis-EWG-Alkane-EWG3-Nitrile

References: 0

Condition to enforce:

R1 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Bischler-Mohlau-Indole-Synthesis

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R6 = L-A
R7 = L-A

Reactants

pH: neutral | no catalyst no_water solvent high temperature

Products

Paal-Knorr-Furan-Synthesis

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Einhorn-Brunner-Reaction

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A, Vinyl-Group

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Oxindole-Synthesis-X-Fluorine

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Isoindolinone-Synthesis-1-X-Bromine

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = H, A-Aliphatic-Carbon
R6 = L-A
R7 = L-A
R8 = L-A
R9 = L-A
R10 = L-A

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Hydrazine-Cyclization-Bromine

References: 0

Reactants

pH: neutral | no catalyst water solvent any temperature

Products

Camps-Quinoline-Synthesis

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst water solvent high temperature

Products

Feist-Benary-Synthesis-X1-Bromine

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent room temperature

Products

Bohlmann-Rahtz-Pyridine-Synthesis-EWG-Carboxyl

References: 0

Condition to enforce:

R1 = L-A, Vinyl-Group
R2 = L-A, Vinyl-Group
R3 = L-A

Avoid formation of:

fragment = 4-membered-ring

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Hydrazine-Cyclization-Iodine

References: 0

Reactants

pH: neutral | no catalyst water solvent any temperature

Products

Barton-Zard-Reaction-SO2Ar

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

pH: basic | no catalyst no_water solvent room temperature

Products

Thiazole-Synthesis

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = L-A

Reactants

no pH | no catalyst water solvent any temperature

Products

Freidlander-Synthesis

References: 0

Condition to enforce:

R5 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Cadogan-Sundberg-Indole-Synthesis

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = L-A
R7 = H, A-Aliphatic-Carbon
R8 = H, A-Aliphatic-Carbon
R9 = H, A-Aliphatic-Carbon
R10 = H, A-Aliphatic-Carbon
R11 = H, A-Aliphatic-Carbon
R12 = H, A-Aliphatic-Carbon

Reactants

pH: neutral | no catalyst any solvent any temperature

Products

Pthalimide-Synthesis-2

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Hanztch-Pyridine-Synthesis

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon
R2 = H, A-Aliphatic-Carbon
R3 = H, A-Aliphatic-Carbon
R4 = H, A-Aliphatic-Carbon
R5 = H, A-Aliphatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent any temperature

Products

Benzimidazolone-Synthesis-1-X-Bromine

References: 0

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: neutral | no catalyst no_water solvent high temperature

Products

VanLeusen-imidazole-synthesis

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A

Reactants

pH: not_acid | no catalyst no_water solvent high temperature

Products

Bradsher-Cyclization-1

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = L-A, A-Aromatic-Carbon
R7 = L-A, A-Aromatic-Carbon
R8 = L-A, A-Aromatic-Carbon
R9 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

pH: acid | no catalyst no_water solvent room temperature

Products

Nitrone-Formation

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Hydrazine-Cyclization-Fluorine

References: 0

Reactants

pH: neutral | no catalyst water solvent any temperature

Products

Azaindole-Synthesis

References: 0

Condition to enforce:

R1 = A-Aromatic-Carbon, L-A
R2 = A-Aromatic-Carbon, L-A
R3 = A-Aromatic-Carbon, L-A
R4 = A-Aromatic-Carbon, L-A
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Davis-Beirut-Reaction

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent high temperature

Products

Iodine-Mediated-Cyclization-Indoline-1

References: 0,1

Condition to enforce:

R2 = A-Aromatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent any temperature

Products

Bischler-Napieralski

References: 0

Condition to enforce:

R1 = L-aromatic
R2 = L-aromatic
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: neutral | no catalyst no_water solvent high temperature

Products

Oxazole-Synthesis-EWG-Carboxyl-EWG3-Nitrile

References: 0

Condition to enforce:

R1 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Kostaneki-Acylation-1

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = L-A, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent any temperature

Products

Indole-Synthesis-1

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = L-A, A-Aromatic-Carbon
R7 = L-A, A-Aromatic-Carbon
R8 = L-A, A-Aromatic-Carbon
R9 = L-A, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Clauson-Kaas

References: 0,1

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Sandmeyer-Isatin-1

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst water solvent room temperature

Products

Pellizzari-Reacion

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A

Reactants

pH: neutral | no catalyst no_water solvent high temperature

Products

Isoindolinone-Synthesis-1-X-Chlorine

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = H, A-Aliphatic-Carbon
R6 = L-A
R7 = L-A
R8 = L-A
R9 = L-A
R10 = L-A

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Niementowski-Quinazoline-Synthesis

References: 0,1

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Amidine-Anhydride-Cyclization

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: neutral | no catalyst no_water solvent any temperature

Products

Bucherer-Carbazole-Synthesis

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = L-A
R7 = L-A
R8 = L-A

Reactants

pH: basic | no catalyst any solvent high temperature

Products

Doebner-Miller

References: 0

Condition to enforce:

R1 = L-A, Vinyl-Group
R2 = L-A, Vinyl-Group
R3 = L-A, Vinyl-Group
R4 = L-A, Vinyl-Group
R5 = L-A, Vinyl-Group
R6 = L-A, Vinyl-Group
R7 = L-A, Vinyl-Group

Reactants

pH: acid | no catalyst water solvent any temperature

Products

Oxazole-Synthesis-EWG-Nitrite-EWG3-Nitrile

References: 0

Condition to enforce:

R1 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Feist-Benary-Synthesis-X1-Chlorine

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent room temperature

Products

Pictet-Gams-Reaction

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A

Reactants

pH: neutral | no catalyst no_water solvent any temperature

Products

Cook-Heilbron-Thiazole-Synthesis

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon

Reactants

pH: basic | no catalyst water solvent any temperature

Products