Index

Imine-Tautomerization-EWG-Phosphonate-EWG3-Nitrile

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

no pH | no catalyst any solvent any temperature

Products

Aston-Greenburg-Rearrangement-X-Bromine

References: 0

Condition to enforce:

R6 = A-Aliphatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent any temperature

Products

Fritsch-Buttenberg-Wiechell-Rearrangement-Cl

References: 0

Condition to enforce:

R1 = A-Aromatic-Carbon
R2 = A-Aromatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent high temperature

Products

Chan-Rearrangement

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst any solvent room temperature

Products

Imine-Tautomerization-EWG-Carbonyl-EWG3-Nitrile

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

no pH | no catalyst any solvent any temperature

Products

Fries-Rearrangement-ortho

References: 0


Special Conditions : SIDE REACTION

Avoid formation of:

fragment = 3-membered-ring, 4-membered-ring, A-Cyclobutene, A-Cyclobutene-Aromatic, A-Cyclobutadiene, A-Cyclo-Double-Aromatic-pentene, A-Cyclopentene-Aromatic, bridged_meta_tether_2, A-Cyclo-Double-Aromatic-Pentene3, bridged_para_tether_2, bridged_para_tether_3, bridged_para_tether_4, bridged_para_tether_5, bridged_meta_tether_1, bridged_meta_tether_2, bridged_meta_tether_3, bridged_meta_tether_4, bridged_meta_tether_5

Reactants

pH: acid | no catalyst any solvent any temperature

Products

Benzilic-Acid-Rearrangement

References: 0

Condition to enforce:

R1 = A-Aromatic-Carbon
R2 = A-Aromatic-Carbon

Reactants

pH: basic | no catalyst water solvent any temperature

Products

Lossen-Rearrangement

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent any temperature

Products

Aston-Greenburg-Rearrangement-X-Chlorine

References: 0

Condition to enforce:

R6 = A-Aliphatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent any temperature

Products

Bamberger-Rearrangement

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst water solvent any temperature

Products

Hofmann-Rearrangement-Cl

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst water solvent room temperature

Products

Eschenmoser-Claisen-Rearrangement

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = L-A
R7 = L-A
R8 = L-A
R9 = L-A

Reactants

pH: neutral | no catalyst no_water solvent high temperature

Products

Mumm-Rearrangement

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

no pH | no catalyst no_water solvent high temperature

Products

Semi-Pinacol-Rearrangement-Alkene

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = H, A-Aliphatic-Carbon
R2 = H, A-Aliphatic-Carbon
R3 = H, A-Aliphatic-Carbon
R4 = H, A-Aliphatic-Carbon
R5 = H, A-Aliphatic-Carbon

Reactants

pH: basic | no catalyst any solvent high temperature

Products

Meisenheimer-Rearrangement

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = H, A-Aliphatic-Carbon
R2 = H, A-Aliphatic-Carbon
R3 = H, A-Aliphatic-Carbon

Reactants

no pH | no catalyst no_water solvent high temperature

Products

Rupe-Rearrangement

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Hayashi rearrangement

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Aston-Greenburg-Rearrangement-X-Sulfonate

References: 0

Condition to enforce:

R6 = A-Aliphatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent any temperature

Products

Curtius-Rearrangement

References: 0,1,2

Condition to enforce:

R1 = H, A-Aliphatic-Carbon

Reactants

no pH | no catalyst no_water solvent high temperature

Products

Criegee-Rearrangement

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

no pH | no catalyst water solvent room temperature

Products

Fritsch-Buttenberg-Wiechell-Rearrangement-Br

References: 0

Condition to enforce:

R1 = A-Aromatic-Carbon
R2 = A-Aromatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent high temperature

Products

Hofmann-Rearrangement-Br

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst water solvent room temperature

Products

Pinacol-Rearrangement

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent any temperature

Products

Meyer-Schuster-Rearrangement

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst water solvent room temperature

Products

Lobry-de-Bruyn-Van-Ekenstein-Transformation

References: 0,1


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: not_neutral | no catalyst any solvent any temperature

Products

Fries-Rearrangement-para

References: 0


Special Conditions : SIDE REACTION

Avoid formation of:

fragment = 3-membered-ring, 4-membered-ring, A-Cyclobutene, A-Cyclobutene-Aromatic, A-Cyclobutadiene, A-Cyclo-Double-Aromatic-pentene, A-Cyclopentene-Aromatic, bridged_meta_tether_2, A-Cyclo-Double-Aromatic-Pentene3, bridged_para_tether_2, bridged_para_tether_3, bridged_para_tether_4, bridged_para_tether_5, bridged_meta_tether_1, bridged_meta_tether_2, bridged_meta_tether_3, bridged_meta_tether_4, bridged_meta_tether_5

Reactants

pH: acid | no catalyst any solvent any temperature

Products

Cornforth-Rearrangement

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon
R2 = H, A-Aliphatic-Carbon
R3 = H, A-Aliphatic-Carbon

Reactants

pH: neutral | no catalyst no_water solvent any temperature

Products

Imine-Tautomerization-EWG-Nitrite-EWG3-Nitrile

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

no pH | no catalyst any solvent any temperature

Products

Semi-Pinacol-Rearrangement-Nu-Sulfonate

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst any solvent high temperature

Products

Imine-Tautomerization-EWG-Carboxyl-EWG3-Nitrile

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

no pH | no catalyst any solvent any temperature

Products

Amadori-Rearrangement

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: not_neutral | no catalyst any solvent room temperature

Products

Semi-Pinacol-Rearrangement-Nu-Chlorine

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst any solvent high temperature

Products

Pummerer-Rearrangement

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst no_water solvent high temperature

Products

Meisenheimer-Rearrangement-Conjugated

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = H, A-Aliphatic-Carbon
R2 = H, A-Aliphatic-Carbon
R3 = H, A-Aliphatic-Carbon
R4 = H, A-Aliphatic-Carbon
R5 = H, A-Aliphatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

Reactants

no pH | no catalyst no_water solvent high temperature

Products

Baker-Venkataraman-Rearrangement

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Avoid formation of:

fragment = 4-membered-ring, A-Cyclobutene-Aromatic

Reactants

pH: basic | no catalyst any solvent any temperature

Products

Piancatelli-Rearrangement

References: 0,1,2


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: acid | no catalyst water solvent any temperature

Products

Aston-Greenburg-Rearrangement-X-Iodine

References: 0

Condition to enforce:

R6 = A-Aliphatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent any temperature

Products

Semi-Pinacol-Rearrangement-Nu-Iodine

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst any solvent high temperature

Products

McFadyen-Stevens-Reaction

References: 0

Condition to enforce:

R1 = L-A
R2 = L-A

Reactants

pH: basic | no catalyst any solvent high temperature

Products

Wolff-rearrangement

References: 0,1

Condition to enforce:

R1 = H, A-Aliphatic-Carbon
R2 = H, A-Aliphatic-Carbon

Reactants

pH: basic | no catalyst no_water solvent any temperature

Products

Imine-Tautomerization-EWG-Nitrile-EWG3-Nitrile

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

no pH | no catalyst any solvent any temperature

Products

Kornblum-DeLaMare-Rearrangement

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon
R2 = H, A-Aliphatic-Carbon
R3 = H, A-Aliphatic-Carbon
R4 = H, A-Aliphatic-Carbon
R5 = H, A-Aliphatic-Carbon

Reactants

pH: neutral | no catalyst any solvent any temperature

Products

Beckmann-Rearrangement

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = H, A-Aliphatic-Carbon
R2 = H, A-Aliphatic-Carbon
R3 = H, A-Aliphatic-Carbon
R4 = H, A-Aliphatic-Carbon

Reactants

pH: acid | no catalyst water solvent any temperature

Products

Semi-Pinacol-Rearrangement-Nu-Bromine

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

pH: basic | no catalyst any solvent high temperature

Products

Chapman-Rearrangement

References: 0


Special Conditions : SIDE REACTION

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R2 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

no pH | no catalyst any solvent high temperature

Products

Thiocarbamate-Resonance

References: 0

Condition to enforce:

R1 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

no pH | no catalyst any solvent any temperature

Products