Index
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Fluorine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Indazole-Lg-Fluorine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Sulfonate-and-Nu-Hydroxyl
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Chlorine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Iodine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Alkane-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Chlorine-and-Nu-Hydroxyl
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Nitrite-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Bromine-and-Nu-Amino
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Phosphonate-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Chlorine-and-Nu-Thiolate
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Sulfonate-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Iodine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Phosphonate-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Chlorine-and-Nu-Thiolate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Chlorine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Iodine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Bromine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Chlorine-and-Nu-Amino
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Sulfonate-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Iodine-and-EWG-Carboxyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Phosphonate-and-EWG2-Phosphonate-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R10 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Phosphonate-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Chlorine-and-EWG-Carbonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Sulfonate-and-EWG-Carboxyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Fluorine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Carboxyl-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Alkoxide-and-EWG-Carbonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Bromine-and-Nu-Hydroxyl
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Sulfonate-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Iodine-and-EWG-Carbonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Sulfonate-and-Nu-Alkoxide
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = L-A, A-Aromatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Nitrite-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Bromine-and-EWG-Carbonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Nitrite-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Bromine-and-Nu-Thiolate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Phosphonate-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Bromine-and-Nu-Thiolate
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Iodine-and-EWG-Carbonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Chlorine-and-Nu-Hydroxyl
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Sulfonate-and-Nu-Thiolate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Fluorine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Chlorine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Alkane-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Nitrite-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Alkane-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Phosphonate-and-EWG2-Alkane-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Fluorine-and-Nu-Amino
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Bromine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Phosphonate-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Iodine-and-Nu-Amino
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Indazole-Lg-Chlorine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Indazole-Lg-Bromine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Iodine-and-Nu-Amino
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Bromine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Fluorine-and-Nu-Alkoxide
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Sulfonate-and-Nu-Amino
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Bromine-and-Nu-Hydroxyl
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Iodine-and-Nu-Hydroxyl
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Nitrite-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Chlorine-and-Nu-Thiolate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Indazole-Lg-Bromine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Chlorine-and-EWG-Nitrile
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Chlorine-and-Nu-Hydroxyl
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Chlorine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Iodine-and-Nu-Thiolate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Fluorine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Alkane-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Sulfonate-and-EWG-Carbonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Carboxyl-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Fluorine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Indazole-Lg-Chlorine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Alkoxide-and-EWG-Carboxyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Fluorine-and-Nu-Alkoxide
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Iodine-and-EWG-Carboxyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Bromine-and-EWG-Carboxyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Alkoxide-and-EWG-Sulfonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Carbonyl-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Nitrile-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Fluorine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Indazole-Lg-Fluorine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Iodine-and-Nu-Hydroxyl
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Chlorine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Nitrite-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Fluorine-and-Nu-Alkoxide
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Nitrile-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Alkane-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Phosphonate-and-EWG2-Alkane-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = H, A-Aliphatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Chlorine-and-EWG-Sulfonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Fluorine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Iodine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Nitrite-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Chlorine-and-Nu-Thiolate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Phosphonate-and-EWG2-Alkane-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = H, A-Aliphatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Chlorine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Iodine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Nitrile-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Indazole-Lg-Iodine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Phosphonate-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Nitrite-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Bromine-and-Nu-Amino
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Bromine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Fluorine-and-Nu-Alkoxide
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Fluorine-and-Nu-Amino
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Carboxyl-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Iodine-and-Nu-Thiolate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Bromine-and-EWG-Sulfonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Pyridine-N-Oxide-Chlorination-Ortho
References: 0
Reactants
Products
Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Bromine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Phosphonate-and-EWG2-Alkane-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Iodine-and-Nu-Thiolate
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Chlorine-and-Nu-Hydroxyl
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Sulfonate-and-EWG-Carboxyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Alkoxide-and-EWG-Nitrile
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Nitrile-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Sulfonate-and-Nu-Thiolate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Thiolate-and-EWG-Sulfonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Bromine-and-EWG-Nitrile
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Phosphonate-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Indazole-Lg-Iodine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Sulfonate-and-EWG-Nitrile
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Iodine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Chlorine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Bromine-and-Nu-Alkoxide
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Iodine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Iodine-and-EWG-Nitrile
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Iodine-and-Nu-Alkoxide
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Iodine-and-EWG-Nitrile
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
Reactants
Products
Nucleophilic-Aromatic-Substitution-Nitric-Acid-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Fluorine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Thiolate-and-EWG-Carbonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Fluorine-and-Nu-Hydroxyl
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Sulfonate-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Chlorine-and-Nu-Amino
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Phosphonate-and-EWG2-Phosphonate-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R10 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Sulfonate-and-Nu-Thiolate
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Iodine-and-Nu-Hydroxyl
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Carboxyl-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Chlorine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Alkane-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Bromine-and-Nu-Alkoxide
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Thiolate-and-EWG-Carboxyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Quelet-Reaction
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Sulfonate-and-EWG-Carbonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Bromine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Nitrile-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Sulfonate-and-Nu-Hydroxyl
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Iodine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Alkane-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Bromine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Nitric-Acid-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Alkane-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Thiolate-and-EWG-Nitrile
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Sulfonate-and-Nu-Hydroxyl
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Fluorine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Bromine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Iodine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Chlorine-and-EWG-Carboxyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Nitrile-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Bromine-and-Nu-Alkoxide
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Chlorine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Carboxyl-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Fluorine-and-Nu-Thiolate
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Alkane-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Nitrite-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Carbonyl-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Bromine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Nitric-Acid-Lg-Fluorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Chlorine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Bromine-and-EWG-Sulfonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Pyridine-N-Oxide-Chlorination-Para
References: 0
Reactants
Products
Nucleophilic-Aromatic-Substitution-Indazole-Lg-Chlorine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Nitrile-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Chlorine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Alkane-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Alkane-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Bromine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Indazole-Lg-Fluorine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Alkane-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Phosphonate-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Nitrile-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Nitrite-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Chlorine-and-Nu-Alkoxide
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Fluorine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Bromine-and-Nu-Amino
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Nitrite-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Fluorine-and-Nu-Amino
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Iodine-and-Nu-Amino
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Phosphonate-and-EWG2-Phosphonate-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R10 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Alkane-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Iodine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Phosphonate-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Nitrile-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Thiolate-and-EWG-Nitrile
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Iodine-and-Nu-Amino
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Fluorine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Alkoxide-and-EWG-Sulfonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Bromine-and-Nu-Alkoxide
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Chlorine-and-Nu-Alkoxide
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Indazole-Lg-Bromine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Chlorine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Indazole-Lg-Bromine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Bromine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Nitrile-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Fluorine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Nitrite-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Carboxyl-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Alkoxide-and-EWG-Nitrile
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Nitric-Acid-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Chlorine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Indazole-Lg-Iodine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Bromine-and-EWG-Nitrile
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Bromine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Sulfonate-and-Nu-Alkoxide
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Fluorine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Sulfonate-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Iodine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Fluorine-and-Nu-Thiolate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Sulfonate-and-EWG-Sulfonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Alkoxide-and-EWG-Carbonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Iodine-and-EWG-Sulfonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Iodine-and-EWG-Sulfonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Sulfonate-and-Nu-Thiolate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = L-A, A-Aromatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Indazole-Lg-Fluorine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Sulfonate-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Chlorine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Sulfonate-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Fluorine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Iodine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Fluorine-and-Nu-Hydroxyl
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Fluorine-and-Nu-Thiolate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Alkoxide-and-EWG-Carboxyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Sulfonate-and-Nu-Amino
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = L-A, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R8 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Sulfonate-and-EWG-Sulfonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Sulfonate-and-Nu-Amino
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Nitrite-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Sulfonate-and-Nu-Hydroxyl
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Nitrite-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Chlorine-and-Nu-Alkoxide
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Iodine-and-Nu-Alkoxide
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Iodine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Carboxyl-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Chlorine-and-Nu-Amino
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Bromine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Chlorine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Alkane-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Fluorine-and-Nu-Hydroxyl
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Fluorine-and-Nu-Hydroxyl
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Phosphonate-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Phosphonate-and-EWG2-Phosphonate-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R10 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Phosphonate-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Iodine-and-Nu-Alkoxide
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Phosphonate-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Iodine-and-Nu-Thiolate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Chlorine-and-Nu-Amino
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Iodine-and-Nu-Alkoxide
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Indazole-Lg-Iodine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Alkane-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Sulfonate-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Nitric-Acid-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Sulfonate-and-Nu-Alkoxide
References:
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Phosphonate-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Nitrite-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Sulfonate-and-Nu-Alkoxide
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Thiolate-and-EWG-Sulfonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Nitrite-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Fluorine-and-Nu-Amino
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Bromine-and-Nu-Hydroxyl
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Sulfonate-and-Nu-Amino
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Thiolate-and-EWG-Carbonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Chlorine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Bromine-and-Nu-Amino
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Bromine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Fluorine-and-Nu-Thiolate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Indazole-Lg-Chlorine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Iodine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Carbonyl-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Thiolate-and-EWG-Carboxyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Chlorine-and-EWG-Carbonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Fluorine-and-Nu-Hydroxyl
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Nitrile-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Iodine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Bromine-and-Nu-Amino
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Bromine-and-Nu-Thiolate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Phosphonate-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Phosphonate-Lg-Bromine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Phosphonate-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Alkane-Lg-Chlorine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Chlorine-and-EWG-Carboxyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Vicarious-Nucleophilic-Substitution-Para-X-Chlorine-and-EWG-Nitrile
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Bromine-and-Nu-Hydroxyl
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Carbonyl-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Chlorine-and-EWG-Sulfonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Chlorine-and-Nu-Alkoxide
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Bromine-and-EWG-Carbonyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Iodine-and-Nu-Alkoxide
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Nitrile-Lg-Iodine
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
Reactants
Products
Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Iodine-and-Nu-Hydroxyl
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Bromine-and-EWG-Carboxyl
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Bromine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Fluorine-and-Nu-Thiolate
References: 0
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Carboxyl-Lg-Sulfonate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
Reactants
Products
Vicarious-Nucleophilic-Substitution-Ortho-X-Sulfonate-and-EWG-Nitrile
Condition to enforce:
R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products
Nucleophilic-Aromatic-Substitution-Lg-Bromine-and-Nu-Thiolate
Condition to enforce:
R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon
Reactants
Products