Index

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Fluorine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Indazole-Lg-Fluorine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Sulfonate-and-Nu-Hydroxyl

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Chlorine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Iodine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Alkane-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Chlorine-and-Nu-Hydroxyl

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Nitrite-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Bromine-and-Nu-Amino

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Phosphonate-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Chlorine-and-Nu-Thiolate

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Sulfonate-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Iodine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Phosphonate-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Chlorine-and-Nu-Thiolate

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Chlorine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Iodine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Bromine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Chlorine-and-Nu-Amino

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Sulfonate-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Iodine-and-EWG-Carboxyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Phosphonate-and-EWG2-Phosphonate-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R10 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Phosphonate-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Chlorine-and-EWG-Carbonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Sulfonate-and-EWG-Carboxyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Fluorine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Carboxyl-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Alkoxide-and-EWG-Carbonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Bromine-and-Nu-Hydroxyl

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Sulfonate-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Iodine-and-EWG-Carbonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Sulfonate-and-Nu-Alkoxide

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = L-A, A-Aromatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Nitrite-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Bromine-and-EWG-Carbonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Nitrite-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Bromine-and-Nu-Thiolate

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Phosphonate-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Bromine-and-Nu-Thiolate

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Iodine-and-EWG-Carbonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Chlorine-and-Nu-Hydroxyl

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Sulfonate-and-Nu-Thiolate

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Fluorine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Chlorine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Alkane-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Nitrite-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Alkane-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Phosphonate-and-EWG2-Alkane-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Fluorine-and-Nu-Amino

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Bromine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Phosphonate-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Iodine-and-Nu-Amino

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Indazole-Lg-Chlorine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Indazole-Lg-Bromine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Iodine-and-Nu-Amino

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Bromine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Fluorine-and-Nu-Alkoxide

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Sulfonate-and-Nu-Amino

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Bromine-and-Nu-Hydroxyl

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Iodine-and-Nu-Hydroxyl

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Nitrite-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Chlorine-and-Nu-Thiolate

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Indazole-Lg-Bromine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Chlorine-and-EWG-Nitrile

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Chlorine-and-Nu-Hydroxyl

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Chlorine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Iodine-and-Nu-Thiolate

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Fluorine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Alkane-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Sulfonate-and-EWG-Carbonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Carboxyl-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Fluorine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Indazole-Lg-Chlorine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Alkoxide-and-EWG-Carboxyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Fluorine-and-Nu-Alkoxide

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Iodine-and-EWG-Carboxyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Bromine-and-EWG-Carboxyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Alkoxide-and-EWG-Sulfonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Carbonyl-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Nitrile-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Fluorine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Indazole-Lg-Fluorine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Iodine-and-Nu-Hydroxyl

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Chlorine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Nitrite-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Fluorine-and-Nu-Alkoxide

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Nitrile-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Alkane-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Phosphonate-and-EWG2-Alkane-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = H, A-Aliphatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Chlorine-and-EWG-Sulfonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Fluorine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Iodine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Nitrite-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Chlorine-and-Nu-Thiolate

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Phosphonate-and-EWG2-Alkane-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = H, A-Aliphatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Chlorine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Iodine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Nitrile-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Indazole-Lg-Iodine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Phosphonate-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Nitrite-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Bromine-and-Nu-Amino

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Bromine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Fluorine-and-Nu-Alkoxide

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Fluorine-and-Nu-Amino

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Carboxyl-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Iodine-and-Nu-Thiolate

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Bromine-and-EWG-Sulfonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Pyridine-N-Oxide-Chlorination-Ortho

References: 0

Reactants

Products

Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Bromine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Phosphonate-and-EWG2-Alkane-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Iodine-and-Nu-Thiolate

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Chlorine-and-Nu-Hydroxyl

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Sulfonate-and-EWG-Carboxyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Alkoxide-and-EWG-Nitrile

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Nitrile-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Sulfonate-and-Nu-Thiolate

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Thiolate-and-EWG-Sulfonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Bromine-and-EWG-Nitrile

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Phosphonate-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Indazole-Lg-Iodine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Sulfonate-and-EWG-Nitrile

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Iodine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Chlorine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Bromine-and-Nu-Alkoxide

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Iodine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Iodine-and-EWG-Nitrile

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Iodine-and-Nu-Alkoxide

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Iodine-and-EWG-Nitrile

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A

Reactants

Products

Nucleophilic-Aromatic-Substitution-Nitric-Acid-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Fluorine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Thiolate-and-EWG-Carbonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Fluorine-and-Nu-Hydroxyl

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Sulfonate-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Chlorine-and-Nu-Amino

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Phosphonate-and-EWG2-Phosphonate-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R10 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Sulfonate-and-Nu-Thiolate

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Iodine-and-Nu-Hydroxyl

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Carboxyl-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Chlorine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Alkane-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Bromine-and-Nu-Alkoxide

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Thiolate-and-EWG-Carboxyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Quelet-Reaction

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Sulfonate-and-EWG-Carbonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Bromine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Nitrile-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Sulfonate-and-Nu-Hydroxyl

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Iodine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Alkane-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Bromine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Nitric-Acid-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Alkane-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Thiolate-and-EWG-Nitrile

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Sulfonate-and-Nu-Hydroxyl

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Fluorine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Bromine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Iodine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Chlorine-and-EWG-Carboxyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Nitrile-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Bromine-and-Nu-Alkoxide

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Chlorine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Carboxyl-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Fluorine-and-Nu-Thiolate

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Alkane-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Nitrite-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Carbonyl-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Bromine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Nitric-Acid-Lg-Fluorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Chlorine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Bromine-and-EWG-Sulfonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Pyridine-N-Oxide-Chlorination-Para

References: 0

Reactants

Products

Nucleophilic-Aromatic-Substitution-Indazole-Lg-Chlorine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Nitrile-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Chlorine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Alkane-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Alkane-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Bromine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Indazole-Lg-Fluorine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Alkane-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Phosphonate-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Nitrile-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Nitrite-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Chlorine-and-Nu-Alkoxide

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Fluorine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Bromine-and-Nu-Amino

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Nitrite-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Fluorine-and-Nu-Amino

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Iodine-and-Nu-Amino

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Phosphonate-and-EWG2-Phosphonate-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R10 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Alkane-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Iodine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Phosphonate-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Nitrile-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Thiolate-and-EWG-Nitrile

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Iodine-and-Nu-Amino

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Fluorine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Alkoxide-and-EWG-Sulfonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Bromine-and-Nu-Alkoxide

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Chlorine-and-Nu-Alkoxide

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Indazole-Lg-Bromine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Chlorine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Indazole-Lg-Bromine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Bromine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Nitrile-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Fluorine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Nitrite-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Carboxyl-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Alkoxide-and-EWG-Nitrile

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Nitric-Acid-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Chlorine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Indazole-Lg-Iodine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Bromine-and-EWG-Nitrile

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Bromine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Sulfonate-and-Nu-Alkoxide

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Fluorine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Sulfonate-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Iodine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Fluorine-and-Nu-Thiolate

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Sulfonate-and-EWG-Sulfonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Alkoxide-and-EWG-Carbonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Iodine-and-EWG-Sulfonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Iodine-and-EWG-Sulfonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Sulfonate-and-Nu-Thiolate

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = L-A, A-Aromatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Indazole-Lg-Fluorine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Sulfonate-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Chlorine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Sulfonate-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Fluorine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Iodine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Fluorine-and-Nu-Hydroxyl

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Fluorine-and-Nu-Thiolate

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Alkoxide-and-EWG-Carboxyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Sulfonate-and-Nu-Amino

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = L-A, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R8 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Sulfonate-and-EWG-Sulfonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Sulfonate-and-Nu-Amino

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Nitrite-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Sulfonate-and-Nu-Hydroxyl

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Nitrite-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Chlorine-and-Nu-Alkoxide

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Iodine-and-Nu-Alkoxide

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridazinone-Lg-Iodine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Carboxyl-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Chlorine-and-Nu-Amino

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Bromine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Chlorine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Alkane-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Fluorine-and-Nu-Hydroxyl

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Fluorine-and-Nu-Hydroxyl

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Phosphonate-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Phosphonate-and-EWG2-Phosphonate-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R10 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Phosphonate-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Iodine-and-Nu-Alkoxide

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Phosphonate-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Iodine-and-Nu-Thiolate

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Chlorine-and-Nu-Amino

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Iodine-and-Nu-Alkoxide

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Indazole-Lg-Iodine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Alkane-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aliphatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Sulfonate-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Nitric-Acid-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyrazine-Lg-Sulfonate-and-Nu-Alkoxide

References:

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Phosphonate-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Nitrite-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Sulfonate-and-Nu-Alkoxide

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Thiolate-and-EWG-Sulfonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Nitrite-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Fluorine-and-Nu-Amino

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Bromine-and-Nu-Hydroxyl

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Para-Lg-Sulfonate-and-Nu-Amino

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R7 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Thiolate-and-EWG-Carbonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Chlorine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Bromine-and-Nu-Amino

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Bromine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Fluorine-and-Nu-Thiolate

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Indazole-Lg-Chlorine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-1-2-4-Triazine-Lg-Iodine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Carbonyl-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Thiolate-and-EWG-Carboxyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon
R7 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Chlorine-and-EWG-Carbonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Fluorine-and-Nu-Hydroxyl

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Nitrile-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Iodine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Bromine-and-Nu-Amino

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen
R5 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group-No-Oxygen, A-Alkoxide, Hydroxyl, A-Aliphatic-Nitrogen

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Bromine-and-Nu-Thiolate

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrite-and-EWG2-Phosphonate-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Phosphonate-Lg-Bromine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R9 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Nitrile-and-EWG2-Phosphonate-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Alkane-Lg-Chlorine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = H, A-Aliphatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Chlorine-and-EWG-Carboxyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Vicarious-Nucleophilic-Substitution-Para-X-Chlorine-and-EWG-Nitrile

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Bromine-and-Nu-Hydroxyl

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carbonyl-and-EWG2-Carbonyl-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group
R8 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Chlorine-and-EWG-Sulfonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Chlorine-and-Nu-Alkoxide

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Bromine-and-EWG-Carbonyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Iodine-and-Nu-Alkoxide

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Nitrile-Lg-Iodine

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

Products

Nucleophilic-Aromatic-Substitution-Pyridine-Ortho-Lg-Iodine-and-Nu-Hydroxyl

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Bromine-and-EWG-Carboxyl

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = A-Aromatic-Carbon, A-Aliphatic-Carbon, Vinyl-Group

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Ortho-Lg-Bromine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Pyrimidine-Nucleophilic-Aromatic-Substitution-Lg-Fluorine-and-Nu-Thiolate

References: 0

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Alpha-Acid-EWG1-Carboxyl-and-EWG2-Carboxyl-Lg-Sulfonate

References: 0,1,2,3

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = H, A-Aliphatic-Carbon
R7 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group
R8 = A-Aliphatic-Carbon, A-Aromatic-Carbon, Vinyl-Group

Reactants

Products

Vicarious-Nucleophilic-Substitution-Ortho-X-Sulfonate-and-EWG-Nitrile

References: 0,1

Condition to enforce:

R1 = L-A
R2 = L-A
R3 = L-A
R4 = L-A
R5 = L-A
R6 = H, A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products

Nucleophilic-Aromatic-Substitution-Lg-Bromine-and-Nu-Thiolate

References: 0,1,2,3,4

Condition to enforce:

R1 = L-A, A-Aromatic-Carbon
R2 = L-A, A-Aromatic-Carbon
R3 = L-A, A-Aromatic-Carbon
R4 = L-A, A-Aromatic-Carbon
R5 = L-A, A-Aromatic-Carbon
R6 = A-Aliphatic-Carbon, A-Aromatic-Carbon

Reactants

Products